Genetics & Genomics

Genomic Imprinting : Methods and Protocols

Name: Genomic Imprinting : Methods and Protocols
Brand: Humana Press
SKU: 9780896037410
Price: 12770.00 INR
Availability: InStock
ISBN: 9780896037410

GENOMIC IMPRINTING 2002/E

Contributor(s): Ward, Andrew Editor Format: Hardback

Hardback · ISBN 9780896037410

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Key Specifications

ISBN	9780896037410
Subtitle	GENOMIC IMPRINTING 2002/E
Publisher	Humana Press
Publication date	October 2001
Language	English
MRP	£89.99 GBP
Page count	390
Item weight	152 g

Genomic imprinting is the process by which gene activity is regulated according to parent of origin. Usually, this means that either the maternally inherited or the paternally inherited allele of a gene is expressed while the opposite allele is repressed. The phenomenon is largely restricted to mammals and flowering plants and was first recognized at the level of whole genomes. Nuclear transplantation experiments carried out in mice in the late 1970s established the non-equivalence of the maternal and paternal genomes in mammals, and a similar conclusion was drawn from studies of interploidy crosses of flowering plants that extend back to at least the 1930s. Further mouse genetic studies, involving animals carrying balanced translocations (reviewed in Chapter 3), indicated that imprinted genes were likely to be widely scattered and would form a minority within the mammalian genome. The first imprinted genes were identified in the early 1990s; over forty are now known in mammals and the list continues steadily to expand.

Genomic Imprinting : Methods and Protocols

Key Specifications

Ward, Andrew Editor

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